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Ego Spray is an orange colored special chemical created by the Alchemist. Its main purpose is to shrink someone whenever the user says something negative about him/her. How that works is that the user has to be sprayed by the chemical, and the negative feelings of someone the user says goes towards that certain someone, and a puff of the ego cloud shrinks that victim. Its unknown how long the spray affects the user, though it probably goes away when the user says nice things towards the victims he/she shrunk.

The Alchemist sprays this chemical through his trick flower.

The only users who were affected by the spray were Larry-Boy and Mother Pearl. The Alchemist was about to spray Bob with it, before being thwarted by Herbert and Wally.